Species-specific research literature
NAD+ in dogs, horses
Every canine and equine study below used a precursor — nicotinamide, nicotinic acid, or an NMN/senolytic combination — not NAD+ itself. The 70-dog trial tested a combination product, so the precursor's individual contribution is not isolated.
This page summarises what the published literature covers, and what it does not. It is a bibliography with context, not guidance: Ouralus makes no statement about the use of this compound in any animal, and nothing here is a veterinary recommendation. For laboratory research use only. Not for human consumption.
Scope of the literature
- Species studied
- dogs, horses
- Records cited
- 5
- How these were found
- PubMed, scoped by MeSH species check-tags (Dogs, Cats, Horses). Rodent-only literature was excluded by construction. Every record listed here was re-fetched from NCBI and checked to resolve.
Primary in-vivo studies
Studies carried out in the species named, in living animals.
- A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination.PMID 38811634 ↗
- Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy.PMID 38044436 ↗
- Supplemental Nicotinic Acid Elevates NAD+ Precursors in the Follicular Fluid of Mares.PMID 35681847 ↗
In-vitro work
Cell-culture work using cells of this species. No animal was studied, so this does not stand as independent in-vivo evidence.
- Nicotinamide Mononucleotide Modulates Endothelin-1 via NR4A1 and Histone Modifications in Canine Intestinal Epithelial Cells.Cultured canine intestinal epithelial cells — no animal. Not independent in-vivo evidence.PMID 41751051 ↗
Reviews
Secondary literature. Listed for context; a review is not independent evidence and its underlying studies are counted above where they qualify.
- Can Nicotinamide Adenine Dinucleotide (NAD+) and Sirtuins Be Harnessed to Improve Mare Fertility?Indexed Review. Not independent evidence.PMID 38254361 ↗
What this page does not establish
A 70-dog randomized placebo-controlled trial in canine cognitive dysfunction, the GRMD dystrophy model, and NAD+ precursors in mare follicular fluid. Only three of five cited records are primary in-vivo animal studies.
Research-literature characterization, provided for research context only. For laboratory research use only. Not for human consumption.
Product record: NAD+