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Ouralusouralus
Research question

What is SS-31's described mechanism?

The short answer

Answered from published research literature only. It describes what that literature examines; it is not a statement about use in people. SS-31 is investigational research material and is not an approved product.

SS-31 is characterised as a mitochondria-targeting tetrapeptide that associates with cardiolipin in the inner mitochondrial membrane. The published mechanism work concerns that association and its effect on membrane organisation.3227333923813215

Binding studies report interaction with lipid bilayers, and the mechanism literature maps the protein interactions that follow from it.3227333932554501

Cited literature

  1. The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of actionMitchell W, et al. · Journal of Biological Chemistry · 2020PMID 32273339 ↗
  2. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipinBirk AV, et al. · Journal of the American Society of Nephrology · 2013PMID 23813215 ↗
  3. Mitochondrial protein interaction landscape of SS-31Chavez JD, et al. · Proceedings of the National Academy of Sciences · 2020PMID 32554501 ↗

Research-literature characterization, provided for research context only. For laboratory research use only. Not for human consumption.

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