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Ouralusouralus
Research question

What structure-activity work exists on mitochondria-targeted tetrapeptides?

The short answer

Answered from published research literature only. It describes what that literature examines; it is not a statement about use in people. SS-31 is investigational research material and is not an approved product.

Structure-activity work on this tetrapeptide class varies the residues and reports how bilayer association and interaction profile change with them.3591304432554501

The interaction landscape has been mapped directly, which is what a structure-activity series is measured against.3255450132273339

Cited literature

  1. Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compoundsMitchell W, et al. · eLife · 2022PMID 35913044 ↗
  2. Mitochondrial protein interaction landscape of SS-31Chavez JD, et al. · Proceedings of the National Academy of Sciences · 2020PMID 32554501 ↗
  3. The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of actionMitchell W, et al. · Journal of Biological Chemistry · 2020PMID 32273339 ↗

Research-literature characterization, provided for research context only. For laboratory research use only. Not for human consumption.

Where to read more